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Pharmaceutical Intermediates Afatinib API and intermediates (E)-4-(Dimethylamino)-2-butenoic acid hydrochloride CAS 848133-35-7, US $ 1 - 100 / Kilogram, 848133-35-7, trans-4-Dimethylaminocrotonic acid hydrochloride, C6H12ClNO2.Source from Arshine Pharmaceutical Co., Limited on Waimaotong.com.